ENANTIOSELECTIVE OTUD7B FRAGMENT DISCOVERY THROUGH CHEMOPROTEOMICS SCREENING AND HIGH-THROUGHPUT OPTIMISATION

Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation

Abstract Deubiquitinating enzymes (DUBs) are key regulators of LADIES PANTS URBAN cellular homoeostasis, and their dysregulation is associated with several human diseases.The ovarian tumour protease (OTU) family of DUBs are biochemically well-characterised and of therapeutic interest, yet only a few tool compounds exist to study their cellular func

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DOES Sketchup Make Improve Students’ Visual-Spatial Skills?

This study was conducted with two objectives: (a) to develop 3D geometry teaching strategies through SketchUp Make (SPPD-SUM), and (b) to study the effect of SPPD-SUM on visual-spatial skills (VSS).It was conducted in two stages.Stage I involved designing SPPD-SUM, whereas Stage II involved studying of the effect of SPPD-SUM on VSS.The activities i

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